专    业：

细胞生物学

姓    名：

纪洪杰

职    称：

副教授

研究领域：

再生医学与组织工程

邮    箱：

jihongjie@sdsmu.edu.cn

电    话：

15610278820

代表性论文

1. Hongjie Ji#, Yongjie Zhou#, Xiang Zhuang, Yongjie Zhu, Zhenru Wu, Yanrong Lu, Shengfu Li, Yong Zeng, Qing R Lu, Yanying Huo, Yujun Shi*, Hong Bu. HDAC3 Deficiency Promotes Liver Cancer through a Defect in H3K9ac/H3K9me3 Transition. Cancer Research, 2019,79(14),3676-3688.

2. Min Wang, Zu Hua Qiu, Yu Zhuo Wang, Bo Lian, Jing Kun Bai, Yong Jie Zhou* and Hong Jie Ji*. Analysis of the expression and prognostic significance of DDK complex in Hepatocarcinoma. BMC Cancer, 2023, 23(19).

3. Wenxue Guo, Jie Hao, Min Wang, Tao Huang, Changqing Miao, Luchang Yin, Hongjie Ji*, Fei Gao*, Baolong Zhou*. Polypyrrole hydrogel with near-infrared light-driven nitric oxide release and photothermal activities for rapid synergistic sterilization and infected wound therapy. Colloids and Surfaces A:Physicochemical and Engineering Aspects. 2023, 677: 132411.

4. Hongjie Ji, Zuhua Qiu, Yuzhuo Wang, Li Dong, Jie Cao, Bo Lian, Min Wang. The effect of crosslinking concentration, time, temperature and pH on the characteristic of genipin-crosslinked small intestinal submucosa. Materials Today Communications, 2022,104482.

5. Hongjie Ji, Haiming Zhang, Yuzhuo Wang, Zuhua Qiu, Jingliang Wu, Jie Cao,Kexin Xu, Yi Zhang, Yanlin Jiang, Min Wang*.Feasibility of caffeic acid as a crosslinking agent in modifying acellular extracellular matrices.Biochemical and Biophysical Research Communications, 2023, 677: 182-189.

6. Qing Tao^#, Hongjie Ji^#, Yongjie Zhou, Yuke Shu, Yuwei Chen, Mingyang Shao, Zhenru Wu, Menglin Chen, Tao lv, Yujun Shi. HDAC3 controls liver homeostasis more by facilitating DNA damage repair than by regulating transcription in hepatocytes.Laboratory Investigation.2023, 103(6): 100120.

7. Hongjie Ji, Yanrong Lu, Yujun Shi*. Seeds in the Liver. Acta Histochemica, 2017, 119(4), 349–356.

8. Yongjie Zhou, Hongjie Ji, Qing Xu, Xiaoyun Zhang, Xiaoyue Cao, Yuwei Chen, Mingyang Shao, Zhenru Wu, Jie Zhang, Changli Lu, Jiayin Yang, Yujun Shi, Hong Bu. Congenital biliary atresia is correlated with disrupted cell junctions and polarity caused by Cdc42 insufficiency in the liver. Theranostics，2021 May 24;11(15):7262-7275.

9. Jie Xia, Yongjie Zhou, Hongjie Ji, Yujia Wang, Qiong Wu, Ji Bao, Feng Ye, Yujun Shi*, Hong Bu. Loss of histone deacetylases 1 and 2 in hepatocytes impairs murine liver regeneration through Ki67 depletion. Hepatology, 2013,58(6),2089-2098.

10. XiaoYue Cao, HongJie Ji, YongJie Zhou, XuFeng Lu, Jun Yi Shen, ZhenRu Wu, Hong Bu, YuJun Shi. Elevated expression of Gsα in intrahepatic cholangiocarcinoma associates with poor prognosis. Hepatobiliary & Pancreatic Diseases International, 2017,16(6),638-644.

11. Yongjie Zhou, Lei Zhang, Hongjie Ji, Xufeng Lu, Jie Xia, Li Li, Fei Chen, Hong Bu, Yujun Shi*. MiR-17~92 ablation impairs liver regeneration in an estrogen-dependent manner. Journal of Cellular and Molecular Medicine, 2016, 20(5), 939-948.

代表性科研项目

1. 国家自然科学基金青年项目，82002600，BRG1通过调控DBF4表达促胆管癌发生的分子机制研究，24万元，2021.01-2023.12，主持，结题。

2. 潍坊市科技局医学类项目，2020YX045，京尼平交联SIS复合骨髓间充质干细胞修复大鼠胃全层缺损，1万元，2020.10-2022.12，主持，结题。

3. 潍坊医学院博士科研启动基金，SMARCA4/SMARCA2表达异常切换促肝细胞恶性转变及肝癌发生的机制研究，10万元，主持，结题。

编写教材

《分子病理学进展》，参编，2023年1月，第1版，四川大学出版社。