专    业：

细胞生物学

姓    名：

李文芳

职    称：

副教授

研究领域：

组织工程、肿瘤

邮    箱：

linan0072@163.com

电    话：

13840835990

李文芳，中国生物材料学会会员，毕业于大连理工大学生物医学工程专业。主要从事天然药物生物活性、功能性生物材料的开发、组织工程骨软骨及多种肿瘤模型的构建、乳腺癌肺转移发生发展机制等方面的研究。山东省高校青创团队带头人，主持国自然青年基金1项，主持山东省青年基金1项，主持学校博士基金项目1项和教改课题1项。

代表性科研及教改项目：

1. 构建3D工程化共培养模型探究乳腺癌肺转移的发生发展及药效评估，国家自然科学基金(青年基金)，24万，结题，主持；

2. 山东省高等学校青创科技计划创新团队，30万，在研，主持；

3. 基于工程化肿瘤模型探究乳腺癌肺转移发生发展机制，山东省自然科学基金(青年基金)，15万，结题，主持；

4. 基于脱细胞基质肺转移模型中细胞间及细胞-基质间相互作用的研究，潍坊医学院博士科研启动基金，40万，在研，主持。

代表性论文及专利：

1. Hu XY, Su Y, Ma HL, Zhu JJ, Cheng YY, Li WF^*, Zhong YM, Pan B, Song KD^*. Culturing 3D chitosan/gelatin/nano-hydroxyapatite and bone-derived scaffolds in a dynamic environment enhances osteochondral reconstruction. International Journal of Biological Macromolecules. 2024,137892.

2. Yang JY, Wang L, Wu RM, He YN, Zhao Y, Wang WC, Gao, XC, Wang D, Zhao LD, Li WF^*. 3D Bioprinting in Cancer Modeling and Biomedicine: From Print Categories to Biological Applications. ACS omega, 2024, 9(44): 44076–44100.

3. Su Y, Liu YQ, Hu XY, Lu YQ, Zhang JY, Jin WB, Liu W, Shu Y, Cheng YY, Li WF^*, Nie Y, Pan B, Song KD^*. Caffeic acid-grafted chitosan/sodium alginate/nanoclay-based multifunctional 3D-printed hybrid scaffolds for local drug release therapy after breast cancer surgery[J]. Carbohydrate Polymers, 2023,324: 121441.  

4. Wang L, Yang JY, Hu XY, Wang SP, Wang YX, Sun TY, Wang D, Wang WC, Ma HL, Wang YS, Song KD, Li WF^*. A decellularized lung extracellular matrix/chondroitin sulfate/gelatin/chitosan-based 3D culture system shapes breast cancer lung metastasis. Biomaterials Advances, 2023, 152: 213500.

5. Lu YQ, Xu J, Su Y, Fang H, Liu JQ, Lv SY, Cheng YY, Nie Y, Li WF^*, Pan B, Song KD^*. A biocompatible double-crosslinked gelatin/sodium alginate/dopamine/ quaterniazed chitosan hydrogel for wound dressings based on 3D bioprinting technology. Int. J. Bioprinting, 2023, 9(2).

6. Hu XY, Zheng SS, Zhang R, Wang YW, Jiao ZR, Li WF^*, Nie Y, Liu TQ, Song KD^*. Dynamic process enhancement on chitosan/gelatin/nano-hydroxyapatite-bone derived multilayer scaffold for osteochondral tissue repair. Biomaterials Advances, 2022: 112662.

7. Li W, Hu XY, Li YJ, Song KD^*. Cytotoxicity and growth-inhibiting activity of Astragalus polysaccharides against breast cancer via the regulation of EGFR and ANXA1. J Nat. Med-Tokyo, 2021, 75(4):854-870.

8. Li WF, Hu XY, Yang ST, Wang SP, Zhang CH, Wang H, Cheng YY, Wang YW, Liu TQ, Song KD^*. A novel tissue-engineered 3D tumor model for anti-cancer drug discovery. Biofabrication, 2018, 11(1): 015004.

9. Li WF, Hu XY, Wang SP, Jiao ZR, Sun TY, Liu TQ, Song KD^*. Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation. Int. J. Biol. Macromol., 2020, 145: 985-997.

10. Li WF, Song KD^*, Wang SP, Zhang CH, Zhuang ML, Wang YW, Liu TQ. Anti-tumor potential of astragalus polysaccharides on breast cancer cell line mediated by macrophage activation. Mat. Sci. Eng. C-Mater., 2019, 98, 685-695.

11. Li WF, Hu XY, Wang SP, Wang H, Parungao R, Wang YW, Liu TQ, Song KD^*. Detection and evaluation of anti‐cancer efficiency of astragalus polysaccharide via a tissue engineered tumor model. Macromol. Biosci., 2018, 18(11): 1800223.

12. Li WF, Hu XY, Wang SP, Xing Y, Wang H, Nie Y, Liu TQ, Song KD^*. Multiple comparisons of three different sources of biomaterials in the application of tumor tissue engineering in vitro and in vivo. Int. J. Biol. Macromol., 2019, 130, 166–176.

13. Song KD^*, Li WF, Wang H, Zhang Y, Li LY, Wang YW, Wang H, Wang L, Liu TQ. Development and fabrication of a two-layer tissue engineered osteochondral composite using hybrid hydrogel-cancellous bone scaffolds in a spinner flask. Biomed. Mater., 2016, 11(6): 065002.

14. Hu XY, Li WF, Li LY, Lu YG, Wang YW, Parungao R, Zheng SS, Liu TQ, Nie Y, Wang HF, Song KD^*. A biomimetic cartilage gradient hybrid scaffold for functional tissue engineering of cartilage. Tissue Cell, 2019, 58: 84-92.

15. Hu XY, Xu J, Li WF, Li LY, Parungao R, Wang YW, Zheng SS, Nie Y, Liu TQ, Song KD. Therapeutic “tool” in reconstruction and regeneration of tissue engineering for osteochondral repair. Appl. Biochem. Biotech., 2019, 191(2):785-809.

16. Hu XY, Man Y, Li WF, Li LY, Xu J, Parungao R, Wang YW, Zheng SS, Nie Y, Liu TQ, Song KD^*. 3D bio-printing of CS/Gel/HA/Gr hybrid osteochondral scaffolds. Polymers, 2019, 11(10):1601.

17. Wang SP, Guan S, Li WF, Ge D, Xu JQ, Sun CK, Liu TQ, Ma XH. 3D culture of neural stem cells within conductive PEDOT layer-assembled chitosan/gelatin scaffolds for neural tissue engineering. Mat. Sci. Eng. C-Mater.,2018, 93:890-901.

18. Wang SP, Guan S, Xu JQ, Li WF, Ge D, Sun CK, Liu TQ, Ma XH^*. Neural stem cell proliferation and differentiation in the conductive PEDOT-HA/Cs/Gel scaffold for neural tissue engineering. Biomater. Sci-UK, 2017, 5(10): 2024-2034.  

19. 李文芳，孙同毅，李磊，王国娇，王乐，郑志高. 一种三维工程化乳腺癌肺转移模型、构建方法及应用. 专利号：ZL202110472082.X

20. 宋克东，李文芳，李丽颖，胡雪岩，刘天庆. 一种三维肿瘤模型脱细胞多孔支架、构建方法及其应用. 专利号：ZL201711200870.3