专    业：

微生物学、生物与医药

姓    名：

淡文佳

职    称：

副教授

研究领域：

天然药物化学生物学

邮    箱：

danwenjia@sdsmu.edu.cn

电    话：

13227825206

淡文佳，化学生物学博士，副教授，澳门青年学者，山东省教育厅青创团队带头人。研究方向为基于活性天然产物骨架的抗感染或抗作物病原菌小分子化合物，发掘具有应用价值的先导化合物。主持国家及省部级课题2项。近年来，在Journal of Advanced Research和European Journal of Medicinal Chemistry等期刊发表SCI收录论文34篇，其中第一作者或通讯作者论文20篇，授权国家发明专利4项。担任Journal of Medicinal Chemistry和Science Reports等期刊的同行评议员。指导研究生获国家奖学金、校长奖学金和山东省研究生创新成果奖等。

主要社会兼职

1. 中国/美国化学会会员

2. 山东省科技厅专家库专家、全国研究生教育评估监测专家库专家

代表性论文

 1. Haibo Huo^†, Wenjia Dan^†, Libo Qin, Jiaxue Bo , Xiaonan Zhang, Chaofu Yang , Bianxia Bai, Jiahong Ren*, Baojun Shi*, Jian Li*. Novel steroidal /3-carboline derivatives as promising antibacterial candidates against methicillin-resistant Staphylococcus aureus. Spectrochim. Acta A.2025, 329, 125506.

 2. Jiangkun Dai, Wenjia Dan, Yidan Cao, Jixiang Gao, Junru Wang, Jianbo Wan*. Discovery of new quaternized norharmane dimers as potential anti-MRSA agents. J. Adv. Res.2024, 63, 255.

 3. Jinyi Liu, Yidan Cao, Chenggong Xu, Runchu Li, Yingyan Xiong, Yi Wei, Xianghui Meng, Wenjia Dan*, Chunbo Lu*, Jiangkun Dai*. Quaternized antimicrobial peptide mimics based on harmane as potent anti-MRSA agents by multi-target mechanism covering cell wall, cell membrane and intracellular targets. Eur. J. Med. Chem. 2024, 276, 116657.

 4. Jixiang Gao, Jinyi Liu, Tao Yu, Chenggong Xu, Hao Sun, Chunbo Lu, Wenjia Dan*, Jiangkun Dai*. Synthesis of 3-formyl-eudistomin U with anti-proliferation, anti-migration and apoptosis-promoting activities on melanoma cells. BMC Chem.2023, 17, 184.

 5. Jiaoyue Zhang, Qitao Jia, Liqiang Gu, Wenjia Dan*, Jiangkun Dai*. Recent developments of gramine: Chemistry and biological activity. Molecules2023, 28, 5695.

 6. Wenjia Dan^†, Jixiang Gao^†, Jiaoyue Zhang, Yidan Cao, Jinyi Liu, Yifan Sun, Junru Wang, Jiangkun Dai*. Antibacterial activity and mechanism of action of canthin-6-one against Staphylococcus aureus and its application on beef preservation. Food Control2023, 147, 109604.

 7. Wenjia Dan, Yidan Cao, Yifan Sun, Jiaoyue Zhang, Jinyi Liu, Jixiang Gao, Rui Han*, Jiangkun Dai*. Novel N¹or N⁹modified α-carboline analogues as potential ligands in Alzheimer’s disease therapy: Synthesis and neurobiological activity evaluation. Bioorg. Chem.2023, 133, 106378.

 8. Wenjia Dan, Jixiang Gao, Xiaohui Qi, Junru Wang*, Jiangkun Dai*. Antibacterial quaternary ammonium agents: Chemical diversity and biological mechanism. Eur. J. Med. Chem. 2022, 243, 114765.

 9. Jiangkun Dai, Wenjia Dan*, Jianbo Wan*. Natural and synthetic β-carboline as a privileged antifungal scaffolds. Eur. J. Med. Chem. 2022, 229, 114057.

 10. Wenjia Dan, Yujie Xu, Hongling Gu, Jixiang Gao, Jiangkun Dai*. Methylaervine as potential lead compound against cervical carcinoma: Pharmacologic mechanism prediction based on network pharmacology. Curr. Comput-Aid. Drug2022, 18, 73.

 11. Wenjia Dan, Jixiang Gao, Luqi Li, Yingmeng Xu, Junru Wang*, Jiangkun Dai*. Cellular and non-target metabolomics approaches to understand the antifungal activity of methylaervine against Fusarium solani. Bioorg. Med. Chem. Lett.2021, 43, 128068.

 12. Jiangkun Dai, Rui Han, Yujie Xu, Na Li, Junru Wang*, Wenjia Dan*. Recent progress of antibacterial natural products: Future antibiotics candidates. Bioorg. Chem.2020, 101, 103922.

 13. Wenjia Dan, Jiangkun Dai*. Recent developments of chalcones as potential antibacterial agents in medicinal chemistry. Eur. J. Med. Chem.2020, 187, 111980.

代表性科研项目

1. 国家自然科学基金青年基金，2023.01‒2025.12，主持

2. 山东省自然科学基金青年基金，2023.01‒2025.12，主持

3. 校科研启动基金，2019.07‒2022.06，主持