专    业：

微生物学、生物与医药

姓    名：

李莉莉

职    称：

教授

研究领域：

生物医用高分子材料

邮    箱：

lill@nanoctr.cn

电    话：

18618465606

主要社会兼职

1. 抗菌科学与技术论坛大会学术委员会委员

2. 呼吸与危重症专业委员会副主委

3. 抗癌协会纳米肿瘤专业委员会青年委员

4. 智能仿生纳米材料分会委员

5. 第二届纳米地质专业委员会委员

6. 《分析化学》杂志青年编委

7. 《Exploration》杂志学术编辑

代表性论文

1. Zou, P.; Huang, L.; Li, Y.; Liu, D.; Che, J.; Zhao, T.; Li, H.; Li, J.; Cui, Y.-N.; Yang, G.; Li, Z.*; Li, L.-L.*; Gao, C.* Phase-Separated Nano-Antibiotics Enhanced Survival in Multidrug-Resistant Escherichia coli Sepsis by Precise Periplasmic EcDsbA Targeting. Adv Mater2024, n/a, 2407152.

2. Li, P.; Lian, H.; Zhang, Y.; Yi, L.; Yao, J.; Liu, P.; Li, L.-L*.; Liu, X*.; Wang, H.* Peptide-Guided Metal–Organic Frameworks Spatial Assembly Sustain Long-Lived Charge-Separated State to Improve Photocatalytic Performance. ACS Nano 2024. DOI: 10.1021/acsnano.4c05370

3. Qing Ouyang, Chao Wang, Tian Sang, Yan Tong, Jian Zhang, Yulan Chen, Xue Wang, Lingling Wu, Xu Wang, Ran Liu, Pu Chen, Jiaona Liu, Wanjun Shen, Zhe Feng, Li Zhang, Xuefeng Sun, Guangyan Cai, Li-Li Li*, Xiangmei Chen*，Depleting profibrotic macrophages using bioactivated in vivo assembly peptide ameliorates kidney fibrosis, Cell Mol Immunol 2024, 21, 826

4. Xinmiao Lan, Jie Zhong, Regina Huang, Yuhan Liu, Xiaowei Ma, Xuan Li, Dan Zhao, Guangchao Qing, Yuxuan Zhang, Lu Liu, Jinjin Wang, Xu Ma, Ting Luo, Weisheng Guo, Yuji Wang, Li-Li Li*, Yu-Xiong Su*, Xing-Jie Liang * Conformation Dependent Architectures of Assembled Antimicrobial Peptides with Enhanced Antimicrobial Ability. Adv Healthc Mater 2023, 12, 2301688.

5. Wang, X.; Wang, Y.; Tang, M.; Wang, X.; Xue, W.; Zhang, X.; Wang, Y.; Lee, W.-H.; Wang, Y.; Sun, T.-Y.*; Gao, Y.*; Li, L.-L.*, Controlled Cascade-Release and High Selective Sterilization by Core–Shell Nanogels for Microenvironment Regulation of Aerobic Vaginitis. Adv Healthc Mater 2023, 2202432.

6. Wang, L.; Fu, B.; Hou, D.-Y.; Lv, Y.-L.; Yang, G.; Li, C.; Shen, J.-C.; Kong, B.; Zheng, L.-B.; Qiu, Y.; Wang, H.-L.; Liu, C.; Zhang, J.-J.; Bai, S.-Y.; Li, L.-L.*; Wang, H.*; Xu, W.-H.*, PKM2 allosteric converter: A self-assembly peptide for suppressing renal cell carcinoma and sensitizing chemotherapy. Biomaterials 2023, 122060.

7. Zou, P.; Liu, J.; Li, X.; Yaseen, M.; Yao, J.; Liu, L.; Luo, L.; Wang, H.; Shi, X.; Li, Z.; Sun, T.; Gao, Y.; Gao, C.*; Li, L. L.*, A Membrane Curvature Modulated Lipopeptide to Broadly Combat Multidrug-Resistant Bacterial Pneumonia with Low Resistance Risk. ACS Nano 2022, 12(16), 20545.

8. Ren H.^†, Zeng X.-Z.^†, Zhao X.-X.^†, Hou D., Yao H., Yaseen M., Zhao L., Xu W., Wang H., and Li L.-L.*A bioactivated in vivo assembly nanotechnology fabricated NIR probe for small pancreatic tumor intraoperative imaging. Nat Commun2022, 13(1), 418.

9. Liu, J.; Zhang, X.; Zou, P.; Yao, J.; Liu, L.; Cai, Y.; Sun, T.*; Gao, Y.*; Li, L.-L.*, Peptide-based nano-antibiotic transformers with antibiotic adjuvant effect for multidrug resistant bacterial pneumonia therapy. Nano Today 2022, 44, 101505.

10. L.-J. Luo^†, X.-M. Liu^†, X. Zhang, J. Liu, Y. Gao, T.-Y. Sun, L.-L. Li*, Quantitative Detection of In Vivo Aggregation Degree for Enhanced M2 Macrophage MR Imaging, Nano Lett 2022;22(4), 1694-1702.

11. K. Li, R. Li, P. Zou, L. Li, H. Wang, D. Kong, G. Zheng*, L.-L. Li*, Glycopeptide-nanotransforrs eyedrops with enhanced permeability and retention for preventing fundus neovascularization, Biomaterials 2022;281, 121361.

12. D.-Y. Hou^†, W.-Y. Xiao^†, J.-Q. Wang^†, M. Yaseen, Z.-J. Wang, Y. Fei, M.-D. Wang, L. Wang, H. Wang, X. Shi, M.-m. Cai, H.-T. Feng*, W. Xu*, L.-L. Li*, OGA activated glycopeptide-based nano-activator to activate PKM2 tetramerization for switching catabolic pathways and sensitizing chemotherapy resistance, Biomaterials 2022, 121523.

13. Yifei, S.; Jingkai, Z.; Yue, F.; Zhangjian, H.; Xiaoxuan, L., Li-Li, L.*, Lipase-Activated Glycopeptide Nano-assemblies as an Antibiotic Nano-adjuvant to Inhibit Pseudomonas aeruginosa Biofilm and Enhance Antibacterial Activity. SCI CHINA Chem2022, (1674-7291).

14. Cai, J.-Q.; Liu, X.-M.; Gao, Z.-J.; Li, L.-L.*; Wang, H., Chlorophylls derivatives: Photophysical properties, assemblies, nanostructures and biomedical applications. Mater Today2021, 45, 77-92.

15. An, H.-W.; Mamuti, M.; Wang, X.; Yao, H.; Wang, M.-D.; Zhao, L.*; Li, L.-L.*, Rationally designed modular drug delivery platform based on intracellular peptide self-assembly. Exploration2021, 1 (2), 20210153.

16. Lu, S. Z.; Guo, X. Y.; Zou, M. S.*; Zheng, Z. Q.; Li, Y. C.; Li, X. D.; Li, L. L.*; Wang, H.*, Bacteria-Instructed In Situ Aggregation of AuNPs with Enhanced Photoacoustic Signal for Bacterial Infection Bioimaging. Adv Healthc Mater2020, 9 (1), e1901229.

17. Fei, Y.; Wu, J.; An, H. W.; Zhu, K.; Peng, B.; Cai, J.; Zhang, Y.; Li, L. L.*; Wang, H.*; Huang, Z.*, Identification of New Nitric Oxide-Donating Peptides with Dual Biofilm Eradication and Antibacterial Activities for Intervention of Device-Related Infections. J Med Chem2020, 63 (17), 9127-9135.

18. An, H. W.; Fei, Y.; Yan, T. D.; Lu, C. Q.; Wang, M. D.; Ma, T.; Zhao, B. Y.; Nie, J. M.; Tseng, H. R.; Li, L. L.*; Wang, H.*, Gram‐Positive Bacteria Cell Wall Driven Self‐Disassembled Nanovesicles against Methicillin‐Resistant Staphylococcus Aureus. Adv Ther2020, 3 (6), 1900217.

19. Xiao-Xiao Zhao^†, Li-Li Li^†, Ying Zhao^†, Hong-Wei An, Qian Cai, Jia-Yan Lang, Xue-Xiang Han, Bo Peng, Yue Fei, Hao Liu, Hao Qin, Guangjun Nie* and Hao Wang*, In situ Self-Assembled Nanofibers Precisely Position Cancer Associated Fibroblasts for Improved Tumor Imaging, Angew. Chem. Int. Edit.2019, 58(43): 15287-15294 († co-first author).

20. Li-Li Li, Hong-Wei An, Bo Peng, Rui Zheng, Hao Wang * Self-assembled nanomaterials: design principles, the nanostructural effect, and their functional mechanisms as antimicrobial or detection agents. Mater. Horiz.2019, 6(9): 1794-1811.

21. Li-Li Li, Zeng-Ying Qiao*, Lei Wang* and Hao Wang*, Programmable Construction of Peptide-Based Materials in Living Subjects: From Modular Design, Morphological Control to Theranostics, Adv. Mater. 2018, e1804971.

22. Qian Cai†, Yue Fei†, Liming Hu, Zhangjian Huang, Li-Li Li*, and Hao Wang*, Chemotaxis-Instructed Intracellular S. aureus Infection Detection by A Targeting and Self-Assembly Signal-Enhanced Photoacoustic Probe, Nano Lett. 2018, 18, 6229.

23. Li-Li Li†, Sheng-Lin Qiao†, Wei-Jiao Liu, Yang Ma, Dong Wan, Jie Pan, Hao Wang*,Intracellular Construction of Topology-Controlled Polypeptide Nanostructures with Diverse Biological Functions, Nat. Commun., 2017 8, 1276.

24. Sheng-Lin Qiao,†Yang Ma†, Yi Wang, Yao-Xin Lin, Hong-Wei An, Li-Li Li,* and Hao Wang*, A General Approach of Stimuli-Induced-Aggregation for Monitoring Tumor Therapy, ACS Nano, 2017,11, 7301.

25. Li-Li Li^†, Huai-Lei Ma^†, Guo-bin Qi, Di Zhang, Faquan Yu, Zhi-yuan Hu,* Hao Wang,* Pathological Condition Driven Construction of Supramolecular Nano-Assemblies for Bacterial Infection Detection, Adv. Mater. 2016. 28, 254.

26. Li-Li Li^†, Guo-Bin Qi^†, Faquan Yu, Shi-Jie Liu, Hao Wang,* An Adaptive Bio-Interface from Self-Assembled Functional Peptides for Tissue Engineering, Adv. Mater. 2015. 20, 3181

27. Li-Li Li^†, Jun-Hua Xu^†, Guo-Bin Qi, Xingzhong Zhao, Faquan Yu, Hao Wang,* Core–Shell Supramolecular Gelatin Nanoparticles for Adaptive and “On-Demand” Antibiotic Delivery, ACS Nano 2014, 8, 4975

代表性科研项目

责任人负责的项目：

1. 与华北制药集团横向课题“纳米抗生素佐剂制剂及纳米抗生素”，2023.9-2028.8，500

2. 
   

3. 北京市自然科学基金-昌平创新联合基金项目（L234013），“重组人源化胶原蛋白敷料材料AI预测筛选评价及产品研发“，2023.11-2026.12，100

4. 
   

5. 科技部国家重点研发计划（2022YFA1207501），“纳米结构软骨仿生生物墨水研制及其调控软骨再生机制”，2023.5-2028.4，417.7

6. 
   

7. 国家自然基金优秀青年项目（E3041101），“生物医用高分子抗菌材料”2023.1-2025.12，200

8. 
   

9. 与军科院毒理研究所横向课题“耐药菌高亲和仿生多肽自组装纳米载体的表征及体内评价”2022.10-2025.9，46.7

10. 
    

11. 科技部国家重点研发计划（2018YFE0205401），“化学自组装纳米材料的设计与构筑”2019.4-2022.4，227

12. 
    

13. 国家自然基金面上项目（31671028）“活体超分子纳米组装调控及其在细菌感染诊疗中的应用研究”， 2017-2020，65

14. 
    

15. 国家自然基金面上项目（51873045）“多肽聚合物“活体自组装”纳米探针研发及其在胰腺癌核磁共振成像诊断中的应用” 2019-2022，60

16. 
    

17. 中科院青促会，2017-2020，80

18. 
    

19. 国家青年基金项目（51303036），“SiO2-抗生素纳米抗菌剂的制备及在细菌感染诊疗中的应用研究” 2014-2016，25

20. 
    

21. 博士后基金（2013M540902），“SiO2-抗生素纳米抗菌剂对细菌感染治疗的研究” 2014-2015，5

22. 
    

23. 国家纳米科学中心“一三五”建设和卓越中心培育专项，“体内原位构筑超分子聚集体光声造影剂用于活体细菌感染成像研究” 2014-2015，30

24. 
    

责任人参与的项目：

1. 科技部国家重点研发计划（2024YFA1210302）， “肺部炎症病灶靶向型吸入纳米药物的制备及递送规律研究”，2025.01-2029.12，100

2. 
   

3. 国家重大科研仪器研制项目（82427806），“多模态宽光谱膀胱内镜的系统研制及应用”2025.01-2029.12，152.9

4. 
   

专利申请

1. 一种靶向光声造影剂、其制备方法及应用（授权号：ZL201410213818.1）

2. 基于细胞内酶催化聚合的多肽单体分子及其在构建纳米材料中的应用（授权号: ZL201610408076.7）

3. 一种药物递送系统及其制备方法与应用（授权号: ZL201710891549.8）已转让

4. 一种细胞内酶催化聚合构建的类弹性蛋白纳米材料制备方法及其生物应用（授权号: ZL201710361961.9）

5. 一种分子影像探针及其应用（授权号: ZL201810648875.0）

6. 一种多肽抗生素及其制备方法和用途（授权号:ZL201910063935.7）

7. 一种抗菌导尿管机器制备方法和应用（授权号:ZL201910181675.3）

8. 一种SPECT影像探针及其应用201910140825.6

9. 一种多肽单体分子及其自组装纳米材料和应用，（授权号:ZL202111005690.6）

10. 一种多肽聚集体分子及其制备方法和应用，（授权号:ZL202110400881.6）

11. 一种活体自组装MRI成像探针及其制备方法和应用，202110190346.2

12. 一种药物递送载体及其制备方法和应用，（授权号:ZL202110684748.8）

13. 一种能够靶向形变的共组装纳米材料及其制备方法与应用，（授权号:ZL202210931592.3）

14. 一种重组的融合蛋白及其应用，202211202216.7

发表专著

1. Li-Li Li and Hao Wang*, Smart Materials for Tissue Engineering : Fundamental Principles, Eds: Qun Wang, Royal Society of Chemistry., 2017, Print ISBN: 978-1-78262-464-6, 2017; 100-123, Chapter 5; Self-assembled Biomaterials for Tissue Engineering.

2. Eds: Hao Wang and Li-Li Li, In Vivo Self-Assembly Nanotechnology for Biomedical Applications, Springer, Nanomedicine and Nanotoxicology, 2018, Print ISBN: 978-981-10-6912-3.

3. J. Liu, X. Zhang, F.-l. Zhang, Y.-t. Wang, Y.-y. Gao, T.-y. Sun, L.-L. Li*, Chapter 3 Peptide–AIEgen conjugates for biomedical diagnosis and bioimaging, in: T. Ben Zhong, G. Xinggui (Eds.), Volume 1 Aggregation-Induced Emission, De Gruyter, 2022, pp. 31-52.

发表评述

1. L.-L. Li, H. Wang, Infection-targeted bactericidal nanoparticles, Nat Biomed Eng 2018;2(2): 56-57.

科研奖励：

1. 国家自然基金委优秀青年基金获得者

2. 2017入选中国科学院青年促进会成员（中科院青年人才计划）

3. 获2017年中科院青促会“学科交叉与创新”奖