专    业：

微生物学、生物与医药

姓    名：

宋宁宁

职    称：

教授

研究领域：

病原菌致病机制研究

邮    箱：

songningning@sdsmu.edu.cn

电    话：

15205442368

主要社会兼职：

中国防痨协会人兽共患结核病专业分会常务委员；中国中医药信息学会中医临床药学会理事；Frontiers in Cellular and Infection Microbiology客座编缉。

代表性论文:

1. Hui Wang, Xiaotian Li, Shuxian Wang, Ren Fang, Jiayin Xing, Ruiying Wu, Chunhui Zhang, Zhaoli Li and Ningning Song*. Novel target and cofactor repertoire for the transcriptional regulator JTY_0672 from Mycobacterium bovis BCG.  (2025) Frontiers in Microbiology. 15:1464444

2. Ren Fang, Yubao Jin. Weihao Kong, Hui Wang, Shuxian Wang, Xiaotian Li, Jiayin Xing, Yumiao Zhang*, Xingyue Yang*, Ningning Song* .Nano strategies used for combatting the scourge of tuberculosis infections. (2024) Discover Immunity. 1:6

3. Lin Hong, Jiayin Xing, Hui Wang, Shuxian wang, Ren Fang, Xiaotian Li, Zhaoli Li*,Ningning Song*. Roles of Lipolytic Enzymes in Mycobacterium tuberculosis Pathogenesis. (2024) Frontiers in Microbiology.15:1329715

4. Hui Wang, Shuxian Wang, Ren Fang, Xiaotian Li , Jiayin Xing , Zhaoli Li* and Ningning Song*. Enhancing TB Vaccine Efficacy: Current Progress on Vaccines, Adjuvants and Immunization Strategies, (2024) Vaccines, 12, 38.

5. Shuxian Wang, Ren Fang, Hui Wang, Xiaotian Li, Jiayin Xing, Zhaoli Li*and Ningning Song*. The role of transcriptional regulators in metal ion homeostasis of Mycobacterium tuberculosis. (2024) Frontiers in Cellular and Infection Microbiology.14:1360880.

6. Zhitao Wang , Xue Yang , Hui Wang , Shuxian Wang ,Ren Fang , Xiaotian Li , Jiayin Xing , Qianqian Wu ,Zhaoli Li* and Ningning Song*. Characterization and efficacy against carbapenem-resistant Acinetobacter baumannii of a novel Friunavirus phage from sewage. (2024) Frontiers in Cellular and Infection Microbiology.14: 1382145.

7. Siguo Liu*, Ningning Song* and Selvakumar Subbian*. Editorial: The role of transcriptional regulation in mycobacterium physiology. (2024) Frontiers in Cellular and Infection Microbiology. 14:1483263.

8. Yingying Cui, Guanghui Dang, Hui Wang, Yiyi Tang, Mingyue Lv, Siguo Liu*, Ningning Song*. DosR's Multifaceted Role on Mycobacterium bovis BCG Revealed Through Multi-Omics. (2023) Frontiers in Cellular and Infection Microbiology, 13:1292864

9. Xudong Ouyang, Xiaotian Li, Jinmiao Song, Hui Wang, Shuxian Wang, Ren Fang, Zhaoli Li* and Ningning Song*. Mycobacteriophages in diagnosis and alternative treatment of mycobacterial infections. (2023) Frontiers in Microbiology.(10):3389

10. Ningning Song, Henri De Greve, Quanjun Wang, Jean-Pierre Hernalsteens* and Zhaoli Li*. Plasmid parB contributes to uropathogenic Escherichia coli colonization in vivo by acting on biofilm formation and global gene regulation. 2022, 9(1053888). Frontiers in Molecular Biosciences.

11. Yingying Cui; Guanghui Dang; Hui Wang; Yiyi Tang; Mingyue Lv; Xinxin Zang; Zhuming Cai; Ziyin Cui; Jun Cao; Siguo Liu*; Ningning Song*. DosR Regulates the Transcription of the Arginine Biosynthesis Gene Cluster by Binding to the Regulatory Sequences in Mycobacterium bovis Bacille Calmette-Guerin, DNA and cell biology, 2022, 41(12)：1-12.

12. Song Ningning, Zhu Yongqiang, Cui Yingying, Lv Mingyue, Tang Yiyi, Cui Ziyin, Dang Guanghui, Zheng Huajun* and Liu Siguo*. Vitamin B and Vitamin C affect DNA methylation and amino acid metabolism in Mycobacterium bovis BCG (2020)11:812. Frontiers in Microbiology

13. Song Ningning, Li Zhaoli, Cui ziyin, Chen Liping, Cui Yingying, Dang Guanghui, Li Zhe, Li He, Liu Siguo*. The prominent alteration in transcriptome and metabolome of Mycobacterium bovis BCG str. Tokyo 172 induced by vitamin B1. (2019) 19:104. BMC Microbiology

14. Song Ningning, Cui Yingying, Li Zhaoli, Chen Liping, Liu Siguo *. New targets and cofactors for the transcription factor LrpA from Mycobacterium tuberculosis. (2016) DNA and Cell Biology. (35)1-10.

15. Song Ningning, Xu Jie, Li Zhaoli, Hernasteens Jean-Pierre. Curing a large endogenous plasmid by single substitution of a partitioning gene. (2015) Plasmid. (82)10–16.

16. Song Ningning, Nguyen Duc Trong, van Oeffelen Liesbeth, Muyldermans Serge, Peeters Eveline and Daniel Charlier. Expanded target and cofactor repertoire for the transcriptional activator LysM from Sulfolobus. (2013) Nucleic Acids Research. 41(5):2932-49.

17. 吕明月，崔莹莹，唐祎依，党光辉，崔子寅，刘思国*，宋宁宁*. 结核分枝杆菌TetR家族蛋白Rv3295新调控靶点及辅助因子的初步研究. 中国预防兽医学报，2020，42 （5）：643-649

18. 唐祎依，崔莹莹，吕明月，王 慧，党光辉，崔子寅，刘思国*，宋宁宁*.结核分枝杆菌转录调控蛋白Rv0324调控rv3597c的初步研究。中国预防兽医学报，2021，43 （7）：691-697

19. 宋金妙, 冯含笑, 王书贤, 王慧, 刘康凡, 薛永亮, 刘忠*,宋宁宁*. 结核分枝杆菌Lrp/AsnC家族蛋白的研究进展.中国预防兽医学报. 2023.45(4): 434-440

20. 王慧，宋金妙，王书贤，李小田，方仁，郭梦婷，宋宁宁*. 噬菌体在结核病治疗中的研究进展. 2024, 中国预防兽医学报. 46(01):99-106.

21. 王书贤，宋金妙，王慧，李小田，方 仁，郭梦婷，宋宁宁*. 联合组学筛选结核分枝杆菌休眠和复苏过程中潜在靶点的研究进展.中国预防兽医学报.2024.46(3):326-332

22. 王慧，宋金妙，王书贤，李小田，方仁，刑佳音，李兆利*，宋宁宁*.结核疫苗和免疫机制的研究进展.中国预防兽医学报.2024.46（9）977-985.

代表性科研项目

1. 2021.12-2024.12, 山东省青年人才引育创新团队计划项目，主持人。

2. 2024.01-2028.01 鸢都学者特聘专家人才项目

3. 2025.01-2027.12 山东省自然科学基金面上项目，主持人

4. 2019.01-2022.12，双组份调控蛋白Rv3133c(DosR)调控结核分枝杆菌精氨酸合成的机制研究(国家自然科学基金面上项目)，主持。

5. 2017.07-2020.12 国家重点研发计划“畜禽重大疫病防控与高效安全养殖综合技术研发”重点专项“牛羊重要疫病免疫防控新技术研究”项目“牛羊重要疫病免疫防控技术研发”子任务“牛羊病毒疫苗佐剂的研发”主持人。

6. 2015.01-2017.12 结核分枝杆菌LrpA蛋白调控基因转录的机制研究（国家自然科学基金青年项目）, 主持。

7. 2014.10-2017.12 结核分枝杆菌LrpA调控基因转录的机制研究（中国博士后科学基金第56批面上项目二等资助）, 主持。

8. 2014.01-2014.12 Lrp家族蛋白在结核分枝杆菌基因组中的转录调控研究(兽医生物技术国家重点实验室自主研究课题), 主持。

代表性成果

人畜间结核病流行病学的研究及预警模型的建立和应用，获得新疆维吾尔自治区科学技术进步奖三等奖，2017年

编写教材

《兽医微生物学》、《现代马病治疗学》