专    业：

微生物学、生物与医药

姓    名：

代江坤

职    称：

副教授

研究领域：

医药生物技术

邮    箱：

daijkun@hotmail.com

电    话：

18615363833

代江坤，化学生物学博士，中药学博士后，副教授，澳门青年学者，山东省海外优青，山东省教育厅青创团队和山东省卫健委科创团队成员，中国化学会会员，美国化学会会员，世界中医药学会联合会道地药材评价专委会理事，山东生物医学工程学会整合肿瘤专委会委员，Journal of Future Foods、Advanced Biotechnology和Food Science and Human Wellness等期刊青年编委。研究方向为天然药物化学生物学。主持国家及省部级课题4项。近年来，在Journal of Advanced Research和European Journal of Medicinal Chemistry等期刊发表SCI收录论文37篇，其中第一作者或通讯作者论文24篇，授权国家发明专利7项。担任Journal of Medicinal Chemistry等30余种期刊的同行评议员。指导研究生获国家奖学金、校长奖学金和山东省研究生创新成果奖等。

主要社会兼职

1. 世界中医药学会联合会道地药材评价专委会理事

2. 中国/美国化学会会员

3. 山东生物医学工程学会整合肿瘤专委会委员

4. 山东省科技厅专家库专家、全国研究生教育评估监测专家库专家

5. Journal of Future Foods、Advanced Biotechnology和Food Science and Human Wellness等期刊青年编委

代表性论文

 1. Chenggong Xu, Jinyi Liu, Xinrui Li, Wenjia Dan, Chunbo Lu, Jiangkun Dai*. Methoxyl-modulated high-performance ratiometric fluorescent probe with AIE properties for hypochlorite detection and live cell imaging. Spectrochim. Acta A.2025, 329, 125506.

 2. Jiangkun Dai, Wenjia Dan, Yidan Cao, Jixiang Gao, Junru Wang, Jianbo Wan. Discovery of new quaternized norharmane dimers as potential anti-MRSA agents. J. Adv. Res.2024, 63, 255.

 3. Yujie Xu, Congmin Niu, Shuyi Liang, Jiayi Guo, Kaiming Li, Jiarui Zhang, Yaju Jin, Jingkun Bai, Jiangkun Dai*, Chunbo Lu. An inulin-based glycovesicle for pathogen-targeted drug delivery to ameliorate salmonellosis. Int. J. Biol. Macromol. 2024, 267, 131656.

 4. Jinyi Liu, Yidan Cao, Chenggong Xu, Runchu Li, Yingyan Xiong, Yi Wei, Xianghui Meng, Wenjia Dan, Chunbo Lu, Jiangkun Dai*. Quaternized antimicrobial peptide mimics based on harmane as potent anti-MRSA agents by multi-target mechanism covering cell wall, cell membrane and intracellular targets. Eur. J. Med. Chem. 2024, 276, 116657.

 5. Jinyi Liu, Luyao Wang, Yifan Sun, Yingyan Xiong, Runchu Li, Meixia Sui, Zhenzhen Gao, Wei Wang, Hao Sun, Jiangkun Dai*. Antifungal Activity and Multi-Target Mechanism of Action of Methylaervine on Candida albicans. Molecules2024, 29, 4303.

 6. Jixiang Gao, Jinyi Liu, Tao Yu, Chenggong Xu, Hao Sun, Chunbo Lu, Wenjia Dan, Jiangkun Dai*. Synthesis of 3-formyl-eudistomin U with anti-proliferation, anti-migration and apoptosis-promoting activities on melanoma cells. BMC Chem.2023, 17, 184.

 7. Jiaoyue Zhang, Qitao Jia, Liqiang Gu, Wenjia Dan, Jiangkun Dai*. Recent developments of gramine: Chemistry and biological activity. Molecules2023, 28, 5695.

 8. Wenjia Dan, Jixiang Gao, Jiaoyue Zhang, Yidan Cao, Jinyi Liu, Yifan Sun, Junru Wang, Jiangkun Dai*. Antibacterial activity and mechanism of action of canthin-6-one against Staphylococcus aureus and its application on beef preservation. Food Control2023, 147, 109604.

 9. Wenjia Dan, Yidan Cao, Yifan Sun, Jiaoyue Zhang, Jinyi Liu, Jixiang Gao, Rui Han, Jiangkun Dai*. Novel N¹or N⁹modified α-carboline analogues as potential ligands in Alzheimer’s disease therapy: Synthesis and neurobiological activity evaluation. Bioorg. Chem.2023, 133, 106378.

 10. Wenjia Dan, Jixiang Gao, Xiaohui Qi, Junru Wang, Jiangkun Dai*. Antibacterial quaternary ammonium agents: Chemical diversity and biological mechanism. Eur. J. Med. Chem. 2022, 243, 114765.

 11. Jiangkun Dai, Wenjia Dan, Jianbo Wan. Natural and synthetic β-carboline as a privileged antifungal scaffolds. Eur. J. Med. Chem. 2022, 229, 114057.

 12. Wenjia Dan, Yujie Xu, Hongling Gu, Jixiang Gao, Jiangkun Dai*. Methylaervine as potential lead compound against cervical carcinoma: Pharmacologic mechanism prediction based on network pharmacology. Curr. Comput-Aid. Drug2022, 18, 73.

 13. Wenjia Dan, Jixiang Gao, Luqi Li, Yingmeng Xu, Junru Wang, Jiangkun Dai*. Cellular and non-target metabolomics approaches to understand the antifungal activity of methylaervine against Fusarium solani. Bioorg. Med. Chem. Lett.2021, 43, 128068.

 14. Jiangkun Dai, Rui Han, Yujie Xu, Na Li, Junru Wang, Wenjia Dan. Recent progress of antibacterial natural products: Future antibiotics candidates. Bioorg. Chem.2020, 101, 103922.

 15. Wenjia Dan, Jiangkun Dai*. Recent developments of chalcones as potential antibacterial agents in medicinal chemistry. Eur. J. Med. Chem.2020, 187, 111980.

 16. Jiangkun Dai, Wenjia Dan, Siyu Ren, Congguo Shang, Junru Wang. Design, synthesis and biological evaluations of quaternization harman analogues as potential antibacterial agents. Eur. J. Med. Chem.2018. 160, 23.

 17. Jiangkun Dai, Wenjia Dan, Nian Li, Ruixue Wang, Yao Zhang, Nannan Li, Ruizhi Wang, Junru Wang. Synthesis and antibacterial activity of C²or C⁵ modified and D ring rejiggered canthin-6-one analogues. Food Chem.2018, 253, 211.

 18. Jiangkun Dai, Wenjia Dan, Na Li, Junru Wang. Computer-aided drug discovery: Novel 3,9-disubstituted eudistomin U derivatives as potent antibacterial agents. Eur. J. Med. Chem.2018, 157, 333.

 19. Jiangkun Dai, Wenjia Dan, Yunyun Zhang, Junru Wang. Recent developments on synthesis and biological activities of γ-carboline. Eur. J. Med. Chem. 2018, 157, 447.

 20. Jiangkun Dai, Wenjia Dan, Uwe Schneider, Junru Wang* β-Carboline alkaloid monomers and dimers: Occurrence, structural diversity, and biological activities. Eur. J. Med. Chem.2018, 157, 622.

 21. Jiangkun Dai, Wenjia Dan, Yunyun Zhang, Mengfan He, Junru Wang. Design and synthesis of C¹⁰modified and ring-truncated canthin-6-one analogues as effective membrane-active antibacterial agents. Bioorg. Med. Chem. Lett.2018, 28, 3123.

 22. Jiangkun Dai, Wenjia Dan, Na Li, Hongtao Du, Jiwen Zhang, Junru Wang. Synthesis, in vitro antibacterial activities of a series of 3-N-substituted canthin-6-ones. Bioorg. Med. Chem. Lett.2016, 26, 580.

 23. Jiangkun Dai, Na Li, Junru Wang, Schneider Uwe. Fruitful decades for canthin-6-ones from 1952 to 2015: biosynthesis, chemistry, and biological activities. Molecules2016, 21, 493.

代表性科研项目

1. 校科研启动基金，2022.07‒2027.06，主持

2. 山东省优秀青年科学基金（海外），2023.04‒2025.12，主持

3. 国家自然科学基金青年基金，2021.01‒2023.12，主持

4. 山东省自然科学基金青年基金，2021.01‒2023.12，主持

5. 澳门青年学者计划，2020.03‒2022.03，主持