刘子萱,博士后,副教授,长期从事环境化学物质暴露损伤应答基因的调控机制、氧化应激相关信号级联过程和健康效应的研究,主持国家级和省部级等项目共7项,发表SCI论文30余篇,研究成果发表于J Hazard Mater、Part Fibre Toxicol、Environ Pollut、Chemosphere 和 Chem Res Toxicol 等国内外知名期刊。 主要社会兼职 山东省高等学校“青创团队”带头人,山东省医学会分会委员,中国细胞生物学学会,中国化学会,中国环境科学学会等会员 代表性论文 以第一/通讯作者发表的论文 1. Characterization of blood protein adsorption on PM2.5 and its implications on cellular uptake and cytotoxicity of PM2.5. Journal of Hazardous Materials, 2021, 414, 125499.(IF: 14.224) 2. Zinc oxide nanoparticles effectively regulate autophagic cell death by activating autophagosome formation and interfering with their maturation, Particle and Fibre Toxicology, 2020, 17 (1): 46.(IF: 9.112) 3. Iron-bearing nanoparticles trigger human umbilical vein endothelial cells ferroptotic responses by promoting intracellular iron level. Environmental Pollution, 2021, 287, 117345.(IF:9.988) 4. Tetrachlorobenzoquinone exposure triggers ferroptosis contributing to its neurotoxicity. Chemosphere, 2021, 264 (Pt 1): 128413.(IF: 8.943) 5. Polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing DNA damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia BV2 cells. Toxicology, 2021, 152807.(IF:4.571) 6. Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis, Toxicology and Applied Pharmacology, 2020, 407: 115241.(IF: 4.460) 7. Tetrachlorobenzoquinone-Induced Nrf2 Confers Neuron-like PC12 Cells Resistance to Endoplasmic Reticulum Stress via Regulating Glutathione Synthesis and Protein Thiol Homeostasis, Chemical Research in Toxicology, 2018, 31(11): 1230~1239.(IF: 3.973) 8. Effect of Subcellular Translocation of Protein Disulfide Isomerase on Tetrachlorobenzoquinone-Induced Signaling Shift from Endoplasmic Reticulum Stress to Apoptosis, Chemical Research in Toxicology, 2017, 30 (10): 1804~1814. Honor:入选为美国化学会ACS Editors' Choice Article(IF: 3.973) 9. Geniposide attenuates the level of Abeta1-42 via enhancing leptin signaling in cellular and APP/PS1 transgenic mice. Archives of Pharmacal Research. 2017;40 (5):571-578.(IF: 6.010) 10. Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling. Chemical Research in Toxicology. 2016; 29 (9): 1510-1518.(IF: 3.973) 代表性科研项目 1.山东省高等学校青创团队(2023KJ252),2024.01-2026.12,在研,负责人 2.山东省自然科学基金面上项目(ZR2023MB025), 2024.01-2026.12, 在研, 主持 3. 国家自然科学基金青年基金(21906131),2020.01-2022.12,主持 4. 中国博士后科学基金面上资助(2018M643395),2018.11-2021.11,主持 5. 重庆市博士后科研项目特别资助(XmT2018023),2018.10-2021.11,主持 6. 中央高校基本科研业务费(XDJK2016E136),2019.03-2020.12,主持 7. 潍坊医学院博士启动经费,2022.01-2026.12,主持 代表性成果 指导学生获3项国家级和3项省级大学生创新创业项目;指导学生获国家级和省级竞赛奖励10余项。 |