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刘子萱
发布时间:2025-01-24 作者: 浏览次数:10

生命科学与技术学院硕士研究生导师简介

专    业:

生物与医药

姓    名:

刘子萱

职    称:

副教授

研究领域:

心血管疾病发病机制与防治研究

邮    箱:

liuzx0126@126.com

电    话:

18716428307

刘子萱,博士后,副教授,长期从事环境化学物质暴露损伤应答基因的调控机制氧化应激相关信号级联过程和健康效应的研究,主持国家级和省部级等项目共7,发表SCI论文30篇,研究成果发表于J Hazard MaterPart Fibre ToxicolEnviron PollutChemosphere Chem Res Toxicol 等国内外知名期刊

主要社会兼职

山东省高等学校青创团队带头人山东省医学会分会委员中国细胞生物学学会中国化学会,中国环境科学学会会员

代表性论文

以第一/通讯作者发表的论文

1. Characterization of blood protein adsorption on PM2.5 and its implications on cellular uptake and cytotoxicity of PM2.5. Journal of Hazardous Materials, 2021, 414, 125499.IF: 14.224

2. Zinc oxide nanoparticles effectively regulate autophagic cell death by activating autophagosome formation and interfering with their maturation, Particle and Fibre Toxicology, 2020, 17 (1): 46.IF: 9.112

3. Iron-bearing nanoparticles trigger human umbilical vein endothelial cells ferroptotic responses by promoting intracellular iron level. Environmental Pollution, 2021, 287, 117345.IF:9.988

4. Tetrachlorobenzoquinone exposure triggers ferroptosis contributing to its neurotoxicity. Chemosphere, 2021, 264 (Pt 1): 128413.IF: 8.943

5. Polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing DNA damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia BV2 cells. Toxicology, 2021, 152807.IF:4.571

6. Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis, Toxicology and Applied Pharmacology, 2020, 407: 115241.IF: 4.460

7. Tetrachlorobenzoquinone-Induced Nrf2 Confers Neuron-like PC12 Cells Resistance to Endoplasmic Reticulum Stress via Regulating Glutathione Synthesis and Protein Thiol Homeostasis, Chemical Research in Toxicology, 2018, 31(11): 1230~1239.IF: 3.973

8. Effect of Subcellular Translocation of Protein Disulfide Isomerase on Tetrachlorobenzoquinone-Induced Signaling Shift from Endoplasmic Reticulum Stress to Apoptosis, Chemical Research in Toxicology, 2017, 30 (10): 1804~1814. Honor:入选为美国化学会ACS Editors' Choice ArticleIF: 3.973

9. Geniposide attenuates the level of Abeta1-42 via enhancing leptin signaling in cellular and APP/PS1 transgenic mice. Archives of Pharmacal Research. 2017;40 (5):571-578.IF: 6.010

10. Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling. Chemical Research in Toxicology. 2016; 29 (9): 1510-1518.IF: 3.973

代表性科研项目

1.山东省高等学校青创团队(2023KJ252),2024.01-2026.12,在研,负责人

2.山东省自然科学基金面上项目(ZR2023MB025), 2024.01-2026.12, 在研, 主持

3. 国家自然科学基金青年基金(21906131),2020.01-2022.12,主持

4. 中国博士后科学基金面上资助(2018M643395),2018.11-2021.11,主持

5. 重庆市博士后科研项目特别资助(XmT2018023),2018.10-2021.11,主持

6. 中央高校基本科研业务费(XDJK2016E136),2019.03-2020.12,主持

7. 潍坊医学院博士启动经费,2022.01-2026.12,主持

代表性成果

指导学生3项国家级和3项省级大学生创新创业项目指导学生获国家级和省级竞赛奖励10余项。



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