专    业：

微生物学

姓    名：

代江坤

职    称：

副教授

研究领域：

天然药物化学生物学

邮    箱：

daijkun@hotmail.com

电    话：

18615363833

代江坤，化学生物学博士，中药学博士后，副教授，澳门青年学者，山东省海外优青，山东省教育厅青创团队和山东省卫健委科创团队成员，Journal of Future Foods、Advanced Biotechnology和Food Science and Human Wellness等期刊青年编委。研究方向为天然药物化学生物学，主持国家及省部级课题4项。近年来，在Journal of Advanced Research和European Journal of Medicinal Chemistry等期刊发表SCI收录论文43篇，其中第一作者或通讯作者论文30篇，授权国家发明专利7项。担任30余种期刊的同行评议员，指导研究生获国家奖学金（2人）、校长奖学金（1人）和山东省研究生创新成果奖（2项）等。

主要社会兼职

1. 中国/美国化学会会员

2. 山东生物医学工程学会整合肿瘤专委会委员

3. 山东省科技厅专家库专家、全国研究生教育评估监测专家库专家

4. Journal of Future Foods、Advanced Biotechnology和Food Science and Human Wellness等期刊青年编委

代表性论文

1. Runchu Li, Hongwei Lan, Jinyi Liu, Hui Gao, Yi Wei, Gaoteng Huang, Ying Wang, Yuxin Liu, Zihan Zhao, Li Wang, Wenjia Dan, Jiangkun Dai*. Discovery of quaternary ammonium salts fusing β-carboline skeleton as new anti-MRSA agents. Eur. J. Med. Chem.2026, 303, 118431.

2. Chenggong Xu, Hao Sun, Zhongxiang Xin, Wenjuan Rui, Shuo Li, Yifan Zhou, Wenjia Dan, Jiangkun Dai*. Furan-modulated ClO probe with typical turn-on fluorescence response, high signal-to-noise ratio and reactivity for applications in food samples, test strips, live cells and zebrafish. Spectrochim. Acta A. 2026, 348, 127215.

3. Runchu Li, Xiaoxu Yang, Wenjia Dan, Jiangkun Dai*. Natural product-derived antifungals against Candida albicans: Chemical diversity and mechanisms of action. Bioorgan. Med. Chem.2026, 299, 118435.

4. Yingyan Xiong, Panpan Liu, Hui Gao, Yi Wei, Runchu Li, Mengyu Wang, Menglu Cao, Wenjia Dan, Jiangkun Dai*. Discovery of dimethyl quaternary ammonium salt based on harmane against MRSA infections by multi-target mechanism. Eur. J. Med. Chem.2025, 299, 118099.

5. Wenjia Dan, Yingyan Xiong, Runchu Li, Hui Gao, Panpan Liu, Meixia Sui, Chenggong Xu, Jiangkun Dai*. Synthesis and anti-MRSA activity of quaternized small molecule antimicrobial peptide mimics based on norharmane. Eur. J. Med. Chem.2025, 290, 117518.

6. Chenggong Xu, Zhongxiang Xin, Ruishen Yu, Jiaxin Li, Wenjia Dan, Jiangkun Dai*. The control strategies for E. coli O157:H7 in food processing at the physical, chemical and biological levels. Front. Microbiol.2025, 16, 1598090.

7. Meixia Sui, Jiaoyue Zhang, Jingying Li, Li Wang, Zhenzhen Gao, Wenjia Dan, Jiangkun Dai*. Antibacterial activity and multi-target mechanism of harmane against Escherichia coli O157:H7 and its application on ready-to-eat leafy greens. Int. J. Food Microbiol. 2025, 431, 111084.

8. Chenggong Xu, Jinyi Liu, Xinrui Li, Wenjia Dan, Chunbo Lu, Jiangkun Dai*. Methoxyl-modulated high-performance ratiometric fluorescent probe with AIE properties for hypochlorite detection and live cell imaging. Spectrochim. Acta A.2025, 329, 125506.

9. Jiangkun Dai, Wenjia Dan, Yidan Cao, Jixiang Gao, Junru Wang, Jianbo Wan. Discovery of new quaternized norharmane dimers as potential anti-MRSA agents. J. Adv. Res.2024, 63, 255.

10. Yujie Xu, Congmin Niu, Shuyi Liang, Jiayi Guo, Kaiming Li, Jiarui Zhang, Yaju Jin, Jingkun Bai, Jiangkun Dai*, Chunbo Lu. An inulin-based glycovesicle for pathogen-targeted drug delivery to ameliorate salmonellosis. Int. J. Biol. Macromol. 2024, 267, 131656.

代表性科研项目

1. 校科研启动基金，2022.07‒2027.06，主持

2. 山东省优秀青年科学基金（海外），2023.01‒2025.12，主持

3. 国家自然科学基金青年基金，2021.01‒2023.12，主持

4. 山东省自然科学基金青年基金，2021.01‒2023.12，主持

5. 澳门青年学者计划，2020.03‒2022.03，主持