博士后,长期从事动脉粥样硬化、神经疾病和代谢疾病机制研究,主持国家级和省部级等项目共7项,发表SCI论文30余篇,研究成果发表于J Hazard Mater、Part Fibre Toxicol、Environ Pollut、Chem Res Toxicol 等国内外知名期刊。 主要社会兼职 山东省高等学校“青创团队”带头人 山东省医药生物技术学会教学与科普工作委员会副秘书长 山东省医药生物技术学会生物技术临床转化与转移专业委员会委员 山东省医学会医学细胞生物学分会 委员 中国细胞生物学学会、中国化学会、中国环境科学学会等会员 代表性论文 以第一/通讯作者发表的论文 1. Characterization of blood protein adsorption on PM2.5 and its implications on cellular uptake and cytotoxicity of PM2.5. Journal of Hazardous Materials(IF: 14.224) 2. Zinc oxide nanoparticles effectively regulate autophagic cell death by activating autophagosome formation and interfering with their maturation, Particle and Fibre Toxicology(IF: 9.112) 3. Iron-bearing nanoparticles trigger human umbilical vein endothelial cells ferroptotic responses by promoting intracellular iron level. Environmental Pollution(IF:9.988) 4. Polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing DNA damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia BV2 cells. Toxicology(IF:4.571) 5. Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis, Toxicology and Applied Pharmacology(IF: 4.460) 6. Tetrachlorobenzoquinone-Induced Nrf2 Confers Neuron-like PC12 Cells Resistance to Endoplasmic Reticulum Stress via Regulating Glutathione Synthesis and Protein Thiol Homeostasis, Chemical Research in Toxicology(IF: 3.973) 7. Effect of Subcellular Translocation of Protein Disulfide Isomerase on Tetrachlorobenzoquinone-Induced Signaling Shift from Endoplasmic Reticulum Stress to Apoptosis, Chemical Research in ToxicologyHonor:入选为美国化学会ACS Editors' Choice Article(IF: 3.973) 8. Geniposide attenuates the level of Abeta1-42 via enhancing leptin signaling in cellular and APP/PS1 transgenic mice. Archives of Pharmacal Research.(IF: 6.010) 9. Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling. Chemical Research in Toxicology.(IF: 3.973) 代表性科研项目 1.山东省高等学校青创团队(2023KJ252),带头人(1/5),30万元 2.山东省自然科学基金面上项目(ZR2023MB025), 主持(1/5),10万元 3. 国家自然科学基金青年基金(21906131),主持(1/1),30万元 4. 中国博士后科学基金面上资助(2018M643395),主持(1/1),5万元 5. 中央高校基本科研业务费(XDJK2016E136),主持(1/4),10万元 6. 潍坊医学院博士启动经费,主持(1/1) 代表性成果 指导学生获4项国家级和5项省级大学生创新创业项目;指导学生获国家级和省级竞赛奖励20余项。 |